منابع مشابه
Ddh188 1803..1813
Polyglutamine diseases are characterized by neuronal intranuclear inclusions (NIIs) of expanded polyglutamine proteins, indicating the failure of protein degradation. UBB, an aberrant form of ubiquitin, is a substrate and inhibitor of the proteasome, and was previously reported to accumulate in Alzheimer disease and other tauopathies. Here, we show accumulation of UBB in the NIIs and the cytopl...
متن کاملDev101428 1805..1813
Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal fun...
متن کاملJames Marion Sims (1813-1883)
James Marion Sims [5] developed a surgical cure for ruptures of the wall separating the bladder from the vagina [6] during labor, ruptures called vesico-vaginal fistulas, and he developed techniques and tools used to improve reproductive examinations and health care for women in the US during the nineteenth century. Sims's lateral examination position allowed doctors to better see the vaginal c...
متن کامل1212_07_REUMA2_LAV_ORIG_Alcidi:1813 01 REUMA3 Editoriale
To induce heating of deep tissues, an original apparatus, which delivers low power RF, was built. The therapeutic effects were investigated in a group of patients suffering from painful OA of one knee. In this randomized study, the results obtained by RF were compared with the results obtained by transcutaneous electrical nerve stimulation (TENS), which is a well known and largely used techniqu...
متن کاملDmd065748 1847..1854
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: مجلة کلیة الآداب.بنها
سال: 2005
ISSN: 1687-2525
DOI: 10.21608/jfab.2005.54558